Medicinal Chemistry

Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania

Publications

• Mini Review   
  New Microbial Collagenase Inhibitors Discovered
  Author(s): Georgiana Nitulescu*
  
  Antimicrobial resistance is spreading globally, making healthcare specialists fear "a return to the dark age of medicine". Great efforts are being made to develop new antimicrobials or to repurpose discontinued or shelved drugs to be used against resistant "superbugs". Antibiotic resistance develops in part because the antibiotics we use kill the bacteria. However, this creates a strong selection pressure: a resistant bacterium multiplies while its non-resistant competitors die. As a result, resistance will emerge quickly in the presence of that antibiotic. Another option is to simply disable bacteria, reducing their ability to infect the host. In other words, rather than inhibiting bacterial viability, Bacterial pathogenesis and infectivity are mediated by virulence factors. Collagenases are virulence factors produced by a variety of bacteria, .. Read More»
  DOI: 10.37421/2161-0444.2022.12.651

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