Journal of Pharmacognosy & Natural Products

Department of Chemistry, College of Natural and Computational Sciences, Wollega University, Nekemte, Ethiopia

Publications

• Research Article   
  Chemical Constituents of the Stem Barks of Podocarpus falcatus and Evaluation for Antibacterial Activity
  Author(s): Desalegn Abebe Deresa*, Zelalem Abdissa, Getahun Tadesse Gurmessa and Negera Abdissa
  
  Chromatographic separation of equal ratio of CH2Cl2-MeOH extract of the stem barks of Podocarpus falcatus led to the isolation of three compounds namely: 4β-carboxy-19-nor-totarol (1), β-sitosterol (2), 4-hydroxybenzoic acid (3) and (E)-methyl-3, 4, 5-trimethylhex-2-enoate (4). The structures of the compounds were established based on the analysis of 1D and 2D NMR spectroscopic data. These compounds were reported from this plant for the first time. The crude extract and isolated compounds were evaluated for their antibacterial activity using disk diffusion assay method. The crude extract showed a strong activity against S. aureus. Compounds (1) and (2) showed a relatively moderate activity against S. flexineri and S. typhimurium respectively, whereas, compound (3) and (4) demonstrated a strong ac.. Read More»
  DOI: 10.37421/2472-0992.2022.8.175

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