Journal of Bioanalysis & Biomedicine

Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Publications

• Research Article   
  Differentially Expressed Genes for Regulation of Fetal Hemoglobin Induction in Beta Thalassemia
  Author(s): Khare Soumya*, Chatterjee Tanushree, Gupta Shailendra and Patel Ashish
  
  Beta thalassemia is a disorder in which the body is unable to synthesise haemoglobin beta subunit due to deleterious mutations in the β-globin gene that results in underproduction of Adult Haemoglobin (HbA). Fetal Haemoglobin (HbF), which is composed of two α and two γ subunits, has been identified as a potential substitute for HbA with great clinical significance in β-thalassaemic patients. However, in the developmental stages, the expression of HbF is gradually minimized and overtaken by HbA. Our research found that the investigation of blood expression and its relationship to DEGs may aid in elucidating the role of these DEGs in beta thalassemia progression, and an RNA sequencing study indicated that the β globin gene is down regulated. There are 200 genes that are differently expressed in β thalassemia patients compared to healthy controls, as well .. Read More»
  DOI: 10.37421/1948-593X.2023.15.379

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