Cancer Science & Therapy

Department of Clinical Oncology and Nuclear Medicine, Alexandria University, Champollion Street, Alazarita, Alexandria 21131, Egypt

Publications

• Research Article   
  Progesterone Receptor Expression Level Within Immunohistochemically Determined Early Stage Node Negative Luminal-B Breast Cancer: Forecasting Implication, Outcome and Concordance to Oncotype-DX Recurrence Scores
  Author(s): Hala Ahmed Zaghloul*, Lulwah Abduljabbar, Karim Abdel Halim and Miral Mashhour
  
  Purpose: To depict Progesterone Receptor (PR) expression exerted modulations on Oncotype-DX Recurrence Scores (RS) in immunehistochemically determined node-negative luminal-B-like breast cancers with Ki67 between ≥ 14% and <30% alongside their potentials in forecasting the outcome. Methods: The impact of PR variations on Oncotype-Dx RS alongside their implications to the different prognosticators, including adjuvant chemotherapy, local and distant Recurrence-Free Survival (RFS) were scrutinized. Additionally, the concordance of the Hormone Receptor (HR) quantifying approaches devising immune staining and Reverse Transcriptase-Polymerase Reaction (RT-PCR) were statistically particularized. Results: We selected 250 surgically treated node-negative Luminal-B1 (Ki67 ≥ 14%-<20%) and Luminal-B2(Ki.. Read More»
  DOI: 10.37421/1948-5956.2024.16.606

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