Veterinary Science & Technology

Department of Pharmacy, Apollo College of Pharmacy, Anjora Durg 491001, Chhattisgarh, India

Publications

• Research Article   
  Buprenorphine Pharmacokinetics Following Intravenous Administration in Gestating Sheep
  Author(s): Hari Prasad Sonwani*
  
  Pregnant women who are addicted on opioids are frequently treated with buprenorphine, a semi-synthetic opioid. Pregnancy-related buprenorphine pharmacokinetics is little studied. To find out the pharmacokinetics of intravenous buprenorphine in pregnant sheep, we performed a pharmacokinetic study. An intravenous bolus injection containing 10 μg/kg of buprenorphine was administered to 14 pregnant sheep with late gestation. Plasma samples were taken for up to 48 hours following administration. Using an LC/MS/MS approach, the levels of buprenorphine and its metabolite, nor buprenorphine, were measured in plasma. The lower limits of quantification for each drug were 0.01μg/L and 0.04μg/L, respectively. Noncompartmental analysis was used to calculate the pharma-cokinetic parameters. The median (minimum−maximum) pharmacokinetic characteristics were: Cma.. Read More»
  DOI: 10.37421/2157-7579.2024.15.222

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