Journal of Clinical Case Reports

Department of Pediatric Neurology, Ege University School of Medicine, Bornova, Izmir, Turkey

Publications

• Case Report   
  Two Concomitant Cases with Febrile Infection-Related Epilepsy Syndrome (FIRES) treated with “3-Dimensional Combination Treatment Protocol”
  Author(s): Hasan Tekgul*, Ipek Dokurel Cetin, Pınar Yazıcı, Seda Kanmaz, Erdem Simsek, Hepsen Mine Serin, Sanem Yılmaz, Gul Aktan, Bulent Karapınar and Sarenur Gokben
  
  Objective: Febrile Infection-Related Epilepsy Syndrome (FIRES) is an immun-mediated epileptic encephalopathy presents as a febrile infection related super refractory status epilepticus with mortality rate of up to 30% in intensive care unit in spite of pharmacologically induced coma and immunotherapies. Early interventional ketogenic diet and cannabinoids are suggested for treatment with unknown mechanisms. Case presentation: Here we report two concomitant FIRES cases treated with a “3 dimensional combined treatment protocol“ for FIRES including (1); super refractory status epilepticus treatment protocol with intravenous infusion of antiepileptic and anesthetic drugs, (2) immunomodulatory therapies and (3) early interventional anti-epileptogenic therapy (ketogenic diet plus cannabinoids). The therapeutic intensity of the treatment .. Read More»
  DOI: 10.37421/2165-7920.2021.11.1407

  Abstract HTML PDF