Department of Pediatric Neurology, Ege University School of Medicine, Bornova, Izmir, Turkey
Case Report
Two Concomitant Cases with Febrile Infection-Related Epilepsy Syndrome (FIRES) treated with “3-Dimensional Combination Treatment Protocol”
Author(s): Hasan Tekgul*, Ipek Dokurel Cetin, Pınar Yazıcı, Seda Kanmaz, Erdem Simsek, Hepsen Mine Serin, Sanem Yılmaz, Gul Aktan, Bulent Karapınar and Sarenur Gokben
Objective: Febrile Infection-Related Epilepsy Syndrome (FIRES) is an immun-mediated epileptic encephalopathy presents as a febrile infection related super refractory status epilepticus with mortality rate of up to 30% in intensive care unit in spite of pharmacologically induced coma and immunotherapies. Early interventional ketogenic diet and cannabinoids are suggested for treatment with unknown mechanisms.
Case presentation: Here we report two concomitant FIRES cases treated with a “3 dimensional combined treatment protocol“ for FIRES including (1); super refractory status epilepticus treatment protocol with intravenous infusion of antiepileptic and anesthetic drugs, (2) immunomodulatory therapies and (3) early interventional anti-epileptogenic therapy (ketogenic diet plus cannabinoids). The therapeutic intensity of the treatment .. Read More»
DOI:
10.37421/2165-7920.2021.11.1407
Journal of Clinical Case Reports received 1295 citations as per Google Scholar report