Department of Biochemistry and Molecular Biology, Wright State University, Dayton, USA
Brief Report
Complementary Roles of Lipin1 in Enhancing Myofibre Stability and Regeneration in Dystrophic Muscles
Author(s): Hongren Mei*
Duchenne Muscular Dystrophy (DMD) stands as a debilitating condition triggered by mutations in the dystrophin gene. These mutations culminate
in compromised sarcolemmal integrity, initiating a cascade of events marked by progressive myofibre necrosis and deteriorated muscle function.
Earlier investigations from our lab underscored the significance of lipin1 in bolstering skeletal muscle regeneration and upholding myofibre integrity.
Moreover, our studies unveiled a substantial reduction in lipin1 mRNA expression within the skeletal muscle of both DMD patients and the
mdx mouse model, a classic model for DMD. Seeking a deeper comprehension of lipin1's role in dystrophic muscle, we embarked on generating
dystrophin/lipin1 Double Knockout (DKO) mice. Through a comparative analysis encompassing wild-type B10 mice, muscle-specific lipin1 deficient
(lipin1Myf5cKO) mi.. Read More»
DOI:
10.37421/2684-494X.2023.8.70
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