Department of Clinical Pharmacy, Square Hospitals Ltd., West Panthapath, Dhaka, Bangladesh
Research Article
High Dose Tigecycline-Induced Mitochondrial Dysfunction-Associated Acute Metabolic Acidosis: A Retrospective Study
Author(s): Hasan MJ*, Rabbani R, Bachar SC and Huq SMR
Background: Tigecycline (TGC) is a last resort antibiotic having broad spectrum antibacterial activity against
gram-negative bacteria. Beyond its standard dosing regimen, a double dosing regimen has been practicing for
last couple of years to achieve adequate drug concentration in the targeted body tissues. TGC interferes with the
mitochondrial protein translation process and may lead to non-anion gap acute metabolic acidosis (NAGAMA) with
low blood-pH level. The main objective of this retrospective study was to evaluate the frequency of high dose TGCinduced
NAGAMA events in the South Asian critically ill patients.
Methods: The retrospective data of 24 critically ill patients of an intensive care unit (ICU) were considered for
this study. Patients of this study received high dose of TGC. Including all necessary laborato.. Read More»
Molecular and Genetic Medicine received 3919 citations as per Google Scholar report
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