Journal of AIDS & Clinical Research

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, School of Medicine, CRB2, Baltimore, Maryland, 21231, USA

Publications

• Research Article   
  Synergistic Inhibition of HIV-1 Replication by a Combination of Viral Inhibitors Isolated from Compounds Targeting Viral Entry, Integration and Proviral Transcription of Clinical Isolates and Drug-resistant Strains
  Author(s): Ibrahim S. Abd-Elazem, Kiattisak Lugsanangarm, Nadtanet Nunthaboot and Ru Chih C. Huang*
  
  Background: Drug resistance associated with HIV-1 variants emerges due to undetected treatment failures. Therefore, it is urgent to search for an antiretroviral therapy to control HIV replication. We examined the synergistic inhibition of HIV-1 replication by a combination of potential inhibitors against clinical isolates and drug-resistant strains. Methods: Nontoxic, natural product-derived inhibitors, the viral entry inhibitor (Gen-1 (tieghemelin, a triterpenoid saponin)), the integrase inhibitor (M522 (lithospermic acid)), and the transcription inhibitors (G4N (tetraglycylated NDGA) or M4N (tetra-O-methyl-NDGA, terameprocol)) were used to target viral entry, integration, and transcription steps. They have been tested against the replication of an AZT-resistant strain of HIV-1 and clinical isolates from HIV-infected patie.. Read More»
  DOI: 10.37421/2155-6113.2024.15.1031

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