Journal of Clinical Case Reports

Department of Dermatology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland

Publications

• Case Report   
  Erythema Multiforme in a Patient with Reactive Arthritis: Usefulness of Lymphocyte Stimulation Test for Detection of Sulfasalazine Hypersensitivity in a Case Report
  Author(s): Rauno J Harvima* and Ilkka T Harvima
  
  Skin eruption from sulfasalazine (salazosulfapyridine, Salazopyrin-®) was indicated by lymphocyte stimulation test using various concentrations of the metabolites, sulfapyridine and 5-aminosalisylic acid. Only sulfapyridine produced a clear positive stimulation index. Later after about one year, the oral challenge resulted in negative results. The explanation of the developed tolerance for sulfasalazine remains unknown. The results show that Lymphocyte Stimulation Test (LST) can be useful but may necessitate the use of a series of multiple dilutions in case of studying suspected allergens that possess antilymphocytic proliferative properties... Read More»
  DOI: 10.37421/2165-7920.2022.12.1521

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