Molecular Biomarkers & Diagnosis

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

Publications

• Research   
  Association of Serum and Tumor Tissue microRNA Profile with Aggressiveness of Papillary Thyroid Carcinoma in an Iranian Population
  Author(s): Sara Nazari, Ahmad Majd, Iraj Heydari, Mohammad Reza Mohajeri Tehrani and Reza Nekouian*
  
  Objectives: Papillary thyroid carcinoma (PTC) is the most common malignancy of thyroid. We aimed to investigate the association of let-7f, miR-146b-5p, miR-34b, miR-16 and miR-877-5p expression in blood circulation and tumor with aggressiveness of PTC. Methods: A total of 18 patients with aggressive PTC and 18 patients with non-aggressive PTC were studied. The microRNAs expressions were evaluated using real-time PCR. Fold changes (FC) of the miRs in aggressive PTC patients were calculated via calibration with mean of expression of the miRs in non-aggressive groups. Results: MiR-16 showed significant up regulation in blood (FC=2.85; P=0.024), miR-34 showed significant down regulation in blood (FC=0.19; P<0.001) and tumor tissue (FC=0.19; P<0... Read More»
  DOI: 10.37421/2155-9929.2021.12.448

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