Journal of Pharmacognosy & Natural Products

Department of Clinical Research, Kilimanjaro Christian Medical University College, Moshi, Tanzania

Publications

• Review Article   
  Trends in the Design and Discovery of Antibiotics using Natural Products: Bioresources and Capacity Building in Africa
  Author(s): Denis Mteremkoa*, Ernest Mbega, Jaffu Chilongola and Musa Chach
  
  The problem of increase in antibiotic resistance is often linked with the slow pace at which new antibiotic compounds are discovered and developed. Among several other factors, the problem has been exacerbated by most pharmaceutical companies losing interest in new drug discovery and development process owing to insurmountable cost barriers of the drug research and development for novel antibiotic drugs. Most large pharmaceutical companies have abandoned natural product screening for drugs in favour of high throughput screening of chemical libraries consisting of laboratory parallel and massively synthesized small molecules, made by combinatorial chemistry approach, which have often culminated in failure. Recent advances in analytical chemistry, chemical synthetic methods, computational chemistry, computational biophysics, computational biology, genomics, prote.. Read More»
  DOI: 10.37421/2472-0992.2022.8.190

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