Journal of Health & Medical Informatics

USA

Publications

• Extended Abstract   
  Stem Cell Versus The De-De-Differentiation Hypotheses Of Human Carcinogenesis: Adult Human Organ-Specific Stem Cells As Targets For Cancer Stem Cells
  Author(s): James E. Trosko
  
  Human Carcinogenesis appears to fit the “Initiation”, “Promotion”, “Progression” concept, that involves multiple steps and mechanisms.  The two major, but opposing, hypotheses of the origin of this process, by which one normal cell is “initiated” to start this complex evolutionary process, include the “stem cell” hypothesis and the “de-differentiation” or “Re-programming” hypotheses.  With the isolation of human stem cells (embryonic and organ specific adult stem cells), as well as the “induced pluripo.. Read More»
  

  Abstract PDF