Journal of Antimicrobial Agents

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

Publications

• Review Article   
  Antiseptic Action of E-101 Solution, a Myeloperoxidase-Mediated Formulation, in the Presence of Whole Blood Compared to Conventional Wound Antiseptics and Biocides
  Author(s): Gerald A. Denys*, Jessica L. Carpenter, Robert C. Allen and Jackson T. Stephens Jr
  
  E-101 solution is a first-in-class myeloperoxidase containing antimicrobial solution developed for topical application. The active ingredients in E-101 solution are two enzymes, porcine myeloperoxidase (pMPO) and glucose oxidase (GO) in an aqueous solution and activated by the addition of a glucose solution. Once activated, the reactive species hydrogen peroxide, hypochlorous acid/hypochlorite (HOCl/OCl-), and singlet oxygen (1O2) are generated. We evaluated the effect of whole human blood on the performance of E-101 solution compared to commercially available wound antiseptics and commonly used biocides. The wound cleansers NeutroPhase, Microcyn, and Vashe with the active HOCl/OCl- component were tested according to the USP-51 effectiveness test in the presence of 0, 1, 2 and 5% blood. Comparative time-kill studies against chlorhexidine, povidone-iodine, sodium oxychlorosene were t.. Read More»
  

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