Journal of Clinical Anesthesiology: Open Access

Department of Anesthesiology & Pain Medicine, University of Berlin, 14195 Berlin, Germany

Publications

• Mini Review   
  Spleen Function in the Drug metabolism of Monoclonal Antibodies and Nanoparticles
  Author(s): Jessica Myles*
  
  Drugs distribute in the body after absorption, in part to reach target tissues and in part to be disposed of in tissues where they have no clinically relevant effects. Drug metabolism and/or elimination usually end therapeutically relevant effects. The spleen's traditionally attributed role in these fundamental pharmacokinetic processes was clearly marginal. However, due to its high blood flow and microcirculation characteristics, this organ is expected to be significantly exposed to large, new generation drugs that cannot penetrate other tissues with tight endothelial barriers. The spleen is barely mentioned in pharmacology textbooks and among its physiological roles, such as immunological surveillance, removal of aged blood cells, hematopoiesis and blood volume regulation, neither drug disposition nor involvement in pharmacological drug action are ever m.. Read More»
  DOI: 10.37421/2684-6004.2022.6.146

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