Nuclear Medicine & Radiation Therapy

Department of Radiation Oncology, Mayo Clinic; Rochester, MN, USA

Publications

• Short Communication   
  Ascorbate Preferentially Stimulates Gallium-67 Uptake in Glioblastoma Cells
  Author(s): Michael S. Petronek*, M. Li, J.N. Sarkaria, M.K. Schultz and B.G. Allen
  
  Gallium is a tri-valent p-block metal that closely mimics tri-valent iron. Gallium is internalized into cells via transferrin receptor-mediated endocytosis. Both Ga-67 and Ga-68 are radionuclides that can be radiolabeled to various bioactive compounds for clinical imaging procedures to visualize tumors and sites of inflammation. High-dose ascorbate (pharmacological ascorbate) is an emergent glioblastoma therapy that enhances cancer cell-killing through iron-metabolic perturbations. We hypothesized that pharmacological ascorbate treatments might alter Ga-67 uptake in glioblastoma cells. We evaluated the in vitro ability of pharmacological ascorbate to alter gallium uptake in patient-derived glioblastoma cells with variable genetic backgrounds by co-incubating cells with Ga-67 ± pharmacological ascorbate. Surprisingly, we observed increased basal gall.. Read More»
  DOI: 10.37421/2155-9619.2022.13.491

  Abstract HTML PDF