Journal of AIDS & Clinical Research

Senior HIV Pharmacist, North Bristol NHS Trust, UK

Publications

• Brief Report   
  Macrocytosis associated with lamivudine and emtricitabine use in patients with HIV
  Author(s): Clemency Nye*, Joanna Latimer and Mark Gompels
  
  Objectives: The aim of the study was to evaluate the effect of lamivudine on the erythrocyte mean corpuscular volume. Methods: We conducted a retrospective evaluation of the mean corpuscular volume in patients prescribed lamivudine, and a comparison group of patients not taking lamivudine or other NRTIs known to affect the MCV, using electronic patient records from a single UK centre. Results: A total of 456 patients whilst on lamivudine were compared to 483 patients not having taken lamivudine. The mean MCV in the lamivudine group was 94.1 (83-100 fl)., which was statistically significantly higher than that in patients not taking lamivudine, 91.6 fl, including those taking emtricitabine (p-value<0.0001). Of patients prescribed lamivudine, 49 (10%) developed a clinically significant macrocytosis, with an o.. Read More»
  

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