Virology: Current Research

Institute of Science and Technology of Federal University of São Paulo-UNIFESP, in Sao Jose dos Campos, SP, Brazil

Publications

• Research Article   
  Interaction Energies of the Human ACE2 Molecular Recognition by SARS-CoV-2
  Author(s): João Batista Junior*
  
  The Coronaviridae family of viruses includes hundreds of viruses common in many different animal species and humans. Seven coronaviruses (CoVs) are known to cause disease in humans. Four of them show low pathogenicity and are endemic in humans and the other three CoV are particularly dangerous and highly pathogenic viruses, which underwent genetic changes rendering them able to jump the species barriers from animal host to humans and also to spread efficiently among humans. SARS-CoV-2 is the seventh coronavirus known to infect humans. The S protein mediates attachment and viral and host cell membrane fusion. The receptor-binding domains (RBDs) are regions in S protein responsible for receptor recognition. Human angiotensin-converting enzyme 2 (ACE2) is recognized by HCoV-NL63, SARS-CoV and SARS-CoV-2 as their functional receptor. Interaction energy anal.. Read More»
  DOI: 10.37421/vcrh.2020.4.116

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