Archives of Surgical Oncology

Department of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK

Publications

• Mini Review   
  Targeting the PI3K/Akt/mTOR Signaling Pathway in Colorectal Cancer Treatment: Current Insights and Future Perspectives
  Author(s): Johannes Christian*
  
  Colorectal Cancer (CRC) remains a significant global health burden, necessitating the development of novel therapeutic strategies. The PI3K/Akt/ mTOR signaling pathway has emerged as a promising target in CRC due to its pivotal role in regulating cell proliferation, survival, and metabolism. This article provides a comprehensive overview of the dysregulation of the PI3K/Akt/mTOR pathway in CRC and discusses the therapeutic potential of targeting this pathway for CRC treatment. We explore the preclinical and clinical evidence supporting the efficacy of PI3K/Akt/mTOR inhibitors in CRC, highlighting ongoing challenges and future directions in harnessing this pathway for improved patient outcomes... Read More»
  DOI: 10.37421/2471-2671.2024.10.86

  Abstract HTML PDF