Cancer Science & Therapy

Department of Virology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan

Publications

• Research Article   
  High-level Elevation of Transgene Expression via the Joint Effect of Trichostatin A and D-Glucose in a Malignant Pleural Mesothelioma-derived Cell Line Resistant to Adenovirus Vector-based Transgene Expression
  Author(s): Junko Mori*, Yujiro Arao, Tomoyuki Honda and Hiromi Kumon
  
  Objective: Malignant Pleural Mesothelioma (MPM), a locally invasive tumor, is treated with a combination of surgical, radiation, and medical therapies, but the treatment efficacy remains insufficient. Gene therapy for MPM has been attempted to improve the prognosis of the disease, but has not yet reached a practical level. One of the barriers to MPM gene therapy is the resistance of MPM cells to transgene expression. Therefore, the purpose of this study was to find techniques to achieve high-level transgene expression in MPM cells resistant to transgene expression. Methods: We evaluated two MPM cell lines, NCI-H28 (H28) and NCI-H2052 (H2052), for their resistance to transgene expression, and then examined whether transgene expression in the resistant H2052 cells was enhanced by treating the cells with D-glucose, an extracellula.. Read More»
  DOI: 10.37421/1948-5956.2024.16.627

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