Department of Toxicology, Al-Azhar University, Cairo, Egypt
Research Article
Analgesics and Anticancer of Some Synthesized 2-Benzimidazole Derivatives
Author(s): Ahmed Hussein*, Helmy M Sakr, Rezk R Ayyad, Kazem Mahmoud, Ahmed M Mansour and Ahmed G Ahmed
This work, contain some new compounds from benzimidazole derivatives, which synthesized by condensation of Orthophenylene diamine and Carbon disulfide resulting 2-Mercapto-benzimidazole which treated by alcoholic potassium hydroxide forming potassium salt of 2- mercaptobenzimidazole which reacts with different substances (alkyl chloroacetates, chloroacetic chloride, alkyl halides) also the ethoxy carbonyl methyl thiobenzimidazole reacts with different amines in addition to chloromethyl benzimidazole which resulted from the reaction between orthophenylene diamine and chloroacetic acid, which reacted with different amines. The synthesized compound tested as analgesics and anticancer activity the new derivatives revealed moderate, strong and very strong analgesics and moderate and strong anticancer activity... Read More»
Medicinal Chemistry received 6627 citations as per Google Scholar report
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