Journal of Blood & Lymph

Division of Plastic Surgery, Department of Surgery, Northwestern University-Feinberg School of Medicine, Chicago, IL, USA

Publications

• Commentary   
  B Lymphocyte Mediated Immune Response to Silicone Breast Implants: A Short Commentary on a Systematic Review
  Author(s): Puja M. Jagasia, Iulianna C. Taritsa, Kazimir Bagdady and Megan Fracol*
  
  Silicone breast implants have been linked to the development of cancers such as Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) and lesser understood conditions Breast Implant Illness (BII). The pathogenesis of BIA-ALCL has been linked to T-cell activation and proliferation in the capsule of textured breast implants. The effect of silicone breast implants on B cell-mediated immune reactions is not broadly understood. To cultivate a better understanding of how breast implants, affect B-cell mediated immune responses, both local in the capsule and potentially systemically, the authors performed a systematic review. After screening 1096 articles, 39 studies met inclusion criteria. Of the 39 studies meeting inclusion criteria, 23 studied human subjects, 14 studied animal models and 2 studied in vitro models. These studies focused on B cell-.. Read More»
  

  Abstract PDF