Department of Microbiology, University of Hong Kong, Hong Kong
Opinion
Immunopathologic Response that Determines Disease Severity
Author(s): Kenrie Hui*
The host resistant reaction plays a basic part in security from human leishmaniasis as well as in advancing sickness seriousness. In spite of the fact that up-and-comer
quality methodologies in mouse models of leishmaniasis have been very useful, a worldwide comprehension of the safe pathways dynamic in sores from human
patients is deficient. To resolve this issue, vast transcriptional profiling of Leis mania braziliensis-contaminated cutaneous sores and ordinary skin controls was done.
A mark of the L. braziliensis skin sore was characterized, which incorporates more than 2,000 differentially managed qualities. Pathway-level examination of this
transcriptional reaction uncovered key natural pathways present in cutaneous sores, producing a testable 'met pathway' model of immunopathology and giving new
bits of knowledge to treatment of human leishmaniasis... Read More»
DOI:
10.37421/ 2469-9756.2022.8.151
Immunochemistry & Immunopathology received 174 citations as per Google Scholar report