Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3052, Australia
Mini Review
Immune Checkpoint Inhibitors: Revolutionizing Cancer Immunotherapy
Author(s): Kersten Agata*
In the realm of cancer treatment, Immune Checkpoint Inhibitors (ICIs) have emerged as a groundbreaking therapeutic approach, marking a significant paradigm shift in cancer immunology. These inhibitors target key regulatory pathways of the immune system, unleashing its potential
to recognize and eliminate cancer cells. This article explores the mechanism of action, clinical applications, challenges and future prospects
of immune checkpoint inhibitors in cancer therapy. Despite initial responses to ICIs, many patients develop resistance over time, leading to
disease progression. Resistance mechanisms may involve adaptive immune evasion, tumor cell intrinsic factors and alterations in the tumor
microenvironment. Understanding these mechanisms is crucial for developing strategies to overcome resistance and prolong the durability of
response... Read More»
DOI:
10.37421/2476-1966.2024.9.222
Journal of Immunobiology received 34 citations as per Google Scholar report
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