Neurological Disorders

Department of Neurology, MagQu Co., Ltd, Taiwan

Publications

• Research Article   
  Concentration Dependency of Characteristic Times in the Reactions between Protein and Antibody-functionalized Magnetic Nanoparticles via Immunomagnetic Reduction
  Author(s): Huei-Chun Liu, Hsin-Hsien Chen, Ming-Hung Hsu, Kun-Hung Lee and Shieh-Yueh Yang*
  
  Immunomagnetic Reduction (IMR) is an ultrasensitive assay for low-concentrated circulating proteins associated with diseases, such as cancers, inflammation, preterm birth, and neurodegenerative diseases. In addition to exploring clinical utilities, investigations of the chemical kinetics of the associations between biomarker molecules and nanoparticles in IMR have attracted much interest. To this end, the real-time alternating current (AC) magnetic signal, χ ac, of the reagent after being mixed with a sample was recorded, i.e., χac -t curve. Total tau protein (T-Tau), which is associated with neurodegenerative diseases, was used as a representative biomarker. Detailed characterizations, such as characteristic times in the χac -t curve, instant reaction rates, and orders of reactions, were investigated in this work. In particular, the effect of the concentration of the biom.. Read More»
  DOI: 10.4172/2329-6895.11.4.564

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