Department of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India
Short Communication
Discovery of Viral Oncogenes
Author(s): Lakshmi Bhai*
In a wide range of animals and people, retroviruses are cancer-causing. The study of retroviruses has shed light on the mechanisms underlying
human oncogenesis, including the identification of viral and cellular proto-oncogenes. The processes through which non-acute retrovirusesretroviruses
without oncogenes-cause cancer are the focus of this review. The recurring idea is that these cancers develop as a result of viral DNA
integration activating cellular proto-oncogenes by insertional activation. Review of early studies on proto-oncogene insertional activation in cancers
brought on by viruses. Searches for common insertion sites (CISs) in virus-induced malignancies have helped researchers studying non-acute
retroviruses find new proto-oncogenes. Retroviral infection of genetically susceptible mice (retroviral tagging) has been used to discover cellular
proto-on.. Read More»
DOI:
10.37421/2684-494X.2022.7.52
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