Reports in Thyroid Research

Department of Cell and Molecular Biology, University of Karolinska, Stockholm, Sweden

Publications

• Mini Review   
  Artificial Hibernation Physiology
  Author(s): Lisbeth Harder*
  
  Recently reported that 3-T1AM metabolism produces inactive 3-iodothyroacetic acid. In this way, we demonstrated that 3-T1AM's rapid cardiac and thermogenic effects depend on the ethylamine side chain. No iodinated T0AM is produced when 3-T1AM is used as a substrate by Dio1 and Dio3 enzymes, as evidenced by in vitro data. As a result, we were curious about the possibility that deiodination might also function as an inactivation mechanism for 3-T1AM. Due to the fact that T0AM did not cause bradycardia or anapyrexia in mice upon single or repeated administration, our in vivo experiments demonstrate that it does not possess the metabolic, cardiovascular, or thermoregulatory properties of 3-T1AM. Additionally, T0AM did not affect TH homeostasis because it did not affect TH-regulated genes or serum or liver TH concentrations. Previous research has demonstrated that T.. Read More»
  DOI: 10.37421/2684-4273.2022.6.29

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