Journal of Clinical Research

Department of Medicine, Fluminense Federal University, Niterói, RJ, 24033-900, Brazil

Publications

• Research Article   
  Homocysteine, Genomic DNA Methylation and Cell-free DNA Levels as Biomarkers for Glioblastoma Patient's Outcome
  Author(s): Esther Serman, Lorena Adolphsson, Bruno Lima Pessoa and Thereza Quirico-Santos*
  
  Introduction: Glioblastoma (GBM) is characterized by recurrence (rGBM), resistance to chemotherapy and low life expectancy. The methyl grouping pathway plays a crucial role in macromolecule synthesis, gene expression control and maintenance of cellular redox balance. Under physiological conditions, the clearance pathways of homocysteine (Hcys) do not exist in the brain. This work aimed to determine circulating homocysteine levels according to the location of the tumor lesion (lobar or deep). Material and methods: Hcys was dosed by enzymatic method in the serum of 61 patients at the time of inclusion in the Phase I/II study protocol (CONEP 9681 no: 25000.009627/2004-25). Medians were compared between the groups according to tumor location and statistical significance by effect size. Moreover, statistical significance by effe.. Read More»
  DOI: 10.37421/2795-6172.2023.7.187

  Abstract HTML PDF