Neurological Disorders

Department of Emergency and Intensive Care Medicine, Chongqing Medical University, China

Publications

• Research   
  Sirt1 Mediated High-Glucose Induced AΒ Deposition and Cognitive Impairment through Activation of the TLR9/P53 Pathway
  Author(s): Yue Sun, Shiyu Zhu, Jinliang Chen, Yuxing Zhao, Cheng Luo, Lv Qiong, Zhiyin Liao, Kexiang Zhao, Yuan Gao, Di Wang and Qian Xiao*
  
  Aim: DE is a chronic central nervous system complication caused by DM. Aβ² deposition has been considered as the main cause of cognitive impairment in DE. Our study explored the function of non-inflammatory pathway of TLR9, that acting on Sirt1 related Aβ² deposition and cognitive function in DE. Methods: Wide type and TLR9 knockout C57BL/6J mice were randomly divided into a control and a DM group. The DM rat was produced by intraperitoneal injection of STZ. And adeno associated virus was injected into their hippocampi to inhibit Sirt1. 12 weeks later, the rats were tested in water maze and then sacrificed. Hippocampi were for immunohistochemistry, Western blot, and RT-PCR. In vitro HT22 cells were incubated with or without high glucose medium and further intervened with TLR9 antagonist ODN2088 and p53.. Read More»
  DOI: 10.4172/2329-6895.10.2.479

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