Journal of Blood & Lymph

Department of Blood, Zahedan University of Medical Sciences, Sistan and Balochestan, Iran

Publications

• Research Article   
  Evaluation of DNA Methylation and Genes Expression JAK2 and STAT3 Gene in Acute Lymphoblastic Leukemia
  Author(s): Majid Naderi, Maryam Emami*, Mohammad Shojaei, Tahmine Davoodi and Dor Mohammad Kordi Tamandani*
  
  Acute Lymphoblastic Leukemia (ALL) is the most prevalent malignancy among children. The primary therapeutic modality involves the administration of induction chemotherapy alone or in combination with diverse curative strategies. Existing evidence suggests that epigenetic mechanisms may serve as mediators of the influence of inherited genetic variations on phenotypic characteristics. Consequently, our investigation aimed to ascertain the potential role of DNA methylation in mediating the impact of genetic risk loci on childhood ALL. In mammals, the JAK/STAT pathway represents the principal signaling mechanism for a wide array of cytokines and growth factors. Activation of JAK induces cell proliferation, migration, differentiation, and apoptosis. A multitude of therapeutic interventions have been devised to modulate this signaling pathway, exhibiting varying degrees of efficacy and sho.. Read More»
  DOI: 10.37421/2165-7831.2023.13.314

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