Journal of Clinical Anesthesiology: Open Access

Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, India

Publications

• Original Research Article   
  Comparison of Intrathecal Clonidine in Bupivacaine, Bupivacaine only with Placebo in Patients Scheduled for Lower Limb Orthopaedic Surgery
  Author(s): Harsimran Kaur, Aruna Jain and Manpreet Singh*
  
  Background and Objectives: Clonidine is a partially selective alpha-2 adrenergic agonist and has extensively been studied intrathecally in regional anaesthesia. With this background, the present study was conducted to compare the clinical efficacy of two different doses of intrathecal clonidine in hyperbaric bupivacaine with hyperbaric bupivacaine alone in terms of duration of post-operative analgesia, quality of surgical anaesthesia, incidence of hypotension and bradycardia in lower limb orthopedics surgeries. Methods: Total of 150 patients was randomly allocated to 3 groups of 50 patients each. Group I received 2.5 ml of 0.5% hyperbaric bupivacaine+1 ml NS (Normal Saline); Group II received 2.5 ml of 0.5% hyperbaric bupivacaine+0.5 ml clonidine (75 mcg)+0.5 ml NS; group III received 2.5 ml of 0.5% hyperbaric bupivacaine+1 ml clon.. Read More»
  

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