Journal of Oncology Translational Research

cancer biology, COMSATS University, Pakistan, USA

Publications

• Short Communication   
  Nanogel For Breast Cancer Treatment
  Author(s): Masood F
  
  Breast cancer is the most common malignancy in women globally and is a main reason of mortality, thus requiring more therapeutic advancements. The epirubcin (EPI) is an anthracycline. However, the dose-related cardiotoxicity, neurotoxicity and myelosuppression are main problem associated with the use of available formulation of EPI. The poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) is considered as an ideal drug carrier due to its non-toxic, biodegradable and biocompatible nature. The blank and EPI loaded PHBV nanoparticles decorated with folic acid and polyethylene glycol were by prepared by nanoprecipitation method. Temperature sensitive hydrogel was prepared by addition of β-glycerophosphate disodium salt (β-GP) solution to chitosan (CS) solution. The CS/GP hydrogel demonstrated a rapid sol-to-gel transition at 37°C. The addition of folate gr.. Read More»
  DOI: 10.37421/2476-2261.2024.10.263

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