Journal of Clinical Research

Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan

Publications

• Mini Review   
  Discovery of New Autotaxin Inhibitors Using Structure-based Approaches
  Author(s): Meihui Nelson*
  
  The discovery of effective AutoTaXin (ATX) inhibitors is crucial for developing therapies targeting various diseases, including cancer, inflammation and fibrosis. Structure-based drug design has emerged as a powerful strategy to identify and optimize ATX inhibitors with enhanced potency and selectivity. This comprehensive review explores recent advancements in structure-based approaches for discovering ATX inhibitors, encompassing computational modeling, structural biology insights and medicinal chemistry strategies. Key findings highlight successful examples of ATX inhibitor development, including structure-activity relationship studies and mechanism-based drug design. The review discusses challenges, opportunities and future directions in leveraging structure-based approaches to accelerate the discovery of next-generation ATX inhibitors for clinical applicati.. Read More»
  DOI: 10.37421/2795-6172.2024.8.248

  Abstract HTML PDF