Medicinal Chemistry

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R, China

Publications

• Research Article   
  N-Acetyl-L-tyrosine enhances the Inhibition Sensitivity of Procarbazine against Melanoma Targeted Tyrosinase without the Increase of Toxicity
  Author(s): Yuanlin Liu, Wenda Zhu, Chao Zhang, Yanbing Li, Rikang Wang, Yepu He, Fengxia Yan, Meili Yin, Zhenyou Jiang and Heru Chen*
  
  Procarbazine (Pcb) is a component of a chemotherapeutic cocktail in the treatment of melanoma. Unfortunately, Pcb brings about very common adverse effects. In this study, we tried to improve the therapeutically efficacy of Pcb by combination of N-acetyl-L-tyrosine (NAT). We investigated the effect of Pcb/NAT and its underlying mechanism in melanoma via MTT assay, cell cycle assay, ΔΨm assay, Western blotting and in vivo animal model. It was found that combination of Pcb with NAT in 1:1 mole ratio (Pcb/NAT) enhanced the inhibition sensitivity against murine melanoma cells B16/F10 with IC50 value changed from 31.9 ± 1.1 to 14.2 ± 1.1 μM. Similar result was found in K1735 cell line. Compared to Pcb solely, the inhibitory rate of Pcb/NAT against B16/F10-bearing tumor in C57BL/6 mice was 89.4% by 5.8% increase; whilst the volume.. Read More»
  DOI: 10.37421/2161-0444.2021.11.593

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