Journal of Forensic Medicine

Department of Forensic Medicine, University of Murcia, Murcia, Spain

Publications

• Mini Review   
  Association between Immunoglobulin Receptors, Antigen C and Elevated Risk of Chronic Liver Rejection
  Author(s): Miguel Bolarín*
  
  Chronic liver rejection poses a complex challenge in transplantation, as some patients do not respond to increased immunosuppression. Killer cell immunoglobulin-like receptors and their interactions with Class I Human Leukocyte Antigens (HLA-I) play a crucial role in predicting Natural Killer (NK) cell alloreactivity and influencing acute liver graft rejection. However, their relevance in CR remains a subject of debate. In this study, we investigated KIR and HLA genotypes in 513 liver transplant recipients using sequence-specific oligonucleotide (PCR-SSO) methods. We examined KIRs, human leukocyte antigen C (HLA-C) genotypes, KIR gene combinations, and KIR/HLA ligand interactions in the entire cohort and compared them between CR (n=35) and no-ongoing rejection (NCR=478) cases. It was found that the presence of activating KIR (aKIR) genes in recipients (rKIR2DS2+ and rKIR2DS3+) increas.. Read More»
  DOI: 10.37421/2472-1026.2023.8.219

  Abstract HTML PDF