Cardiovascular Diseases & Diagnosis

Department of Cardiology and Cardiovascular Diseases, University of Fudan, Shanghai, China

Publications

• Mini Review   
  Cardiovascular Disorders and Acetylation: Molecular Processes and Clinical Effects
  Author(s): Mingjie Yang*
  
  The post-translational modification (PTM) processes that epigenetically regulate gene expression and transcriptional activity include acetylation. Reversible histone acetylation on lysine deposits administers the collaborations among DNA and histones to intercede chromatin rebuilding and quality record. Acetylation of non-histone proteins hinders cellular function, whereas acetylation of important mitochondrial enzymes controls bioenergetic metabolism. The delicate homeostatic regulation of embryonic development, postnatal maturation, cardiomyocyte differentiation, cardiac remodeling and the onset of various cardiovascular diseases like obesity, diabetes mellitus, cardiometabolic diseases, ischemiareperfusion injury, cardiac remodeling, hypertension and arrhythmias is dependent on the acetylation and deacetylation of functional proteins. Histone acetyltransferase (Caps) and histone de.. Read More»
  DOI: 10.37421/2329-9517.2023.11.551

  Abstract HTML PDF