Mental Disorders and Treatment

Department of Neurology and Neurosurgery, McGill University, Montreal, Canada

Publications

• Mini Review   
  The Role of the Androgen Receptor in Oxytocin Gene Expression: Implications for Mood Disorders
  Author(s): Mirko Diksic*
  
  Oxytocin (OXT), which is synthesised in the hypothalamic paraventricular nucleus (PVN) and then released into various brain areas, may play an important role in a variety of behaviours and neuropsychiatric disorders, including depression. Clinical studies have suggested that testosterone has the opposite effect on these disorders as oxytocin. We began by looking at the expression of OXT in the PVN of fifteen patients with mood disorders and fifteen matched controls using immunocytochemistry (ICC) and the co-localization of OXT and androgen receptor (AR) using double labelling ICC in the post-mortem hypothalamus of fifteen patients with mood disorders and fifteen matched controls. Following that, the in vitro regulatory effect of AR on OXT gene expression was investigated. Scientist discovered that mood disorder patients had higher levels of PVN OXT expression t.. Read More»
  DOI: 10.37421/2471-271X.2022.08.232

  Abstract HTML PDF