Journal of Bioanalysis & Biomedicine

Department of Science, College of Chemical Sciences, University of Kelaniya, Sri Lanka, India

Publications

• Research Article   
  Molecular Docking Study of Coumarin Derivatives Binding to Caspase-7, a Key Player in the Apoptosis Pathway
  Author(s): M.N.A. Seneviratne*
  
  This study is focused on analysis of inhibitory activity of novel molecules in the active site of human caspase-7. Caspase inhibition is an approach for treating multiple diseases such as Osteoarthritis, Alzheimer's disease, Parkinson's disease and Cisplatin induced renal injury. The caspase family of proteins, particularly activated caspase 3, 7 and 8, is widely implicated in cisplatin induced tubular cell apoptosis. Caspase-7 is a popular drug target for Cisplatin induced renal injury. Coumarins are a family of natural compounds with anti-cancer, anti-inflammatory, anti-oxidant and many more therapeutic properties. Coumarin derivatives were used as the ligands for the caspase-7 receptor using a molecular docking approach. The crystal structure of caspase-7 was obtained from the protein data bank, entry 4FDL, and a set of coumarin derivatives were docked in to the pre-equilib.. Read More»
  DOI: 10.37421/1948-593X.2022.14.355

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