Medicinal Chemistry

Interdisciplinary Institute of Indian System of Medicine (IIISM), Department of Pharmaceutical Chemistry, SRM Institute Science and Technology, Kattankulathur, Tamil Nadu, India

Publications

• Review   
  The Journey of Thiazolidinediones as Modulators of PPARs for the Management of Diabetes: A Critical Review
  Author(s): Munwar S* and Ilango K
  
  Thiazolidinediones are a class of well-established antidiabetic drugs, also named as glitazones. Thiazolidinedione structure has been an important structural domain of research, involving design and development of new drugs for the treatment of type 2 diabetes. Extensive research on the mechanism of action and the structural requirements has revealed that the intended antidiabetic activity in type 2 diabetes is due to their agonistic effect on peroxisome proliferator-activated receptor (PPAR) belonging to the nuclear receptor super family. Glitazones have specific affinity to PPARγ, one of the subtypes of PPARs. Certain compounds under development have dual PPARα/γ agonistic activity which might be beneficial in obesity and diabetic cardiomyopathy. Interesting array of hybrid compounds of thiazolidinedione PPARγ agonists exhibited therapeutic po.. Read More»
  DOI: 10.37421/2161-0444.2020.10.547

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