Virology: Current Research

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan, Japan

Publications

• Short Communication   
  Anti-viral and Anti-inflammatory Effects of Camostat and Nafamostat on Influenza Virus and Coronavirus Infections in Human Airway Cells and the Mouse Lungs
  Author(s): Mutsuo Yamaya* and Hidekazu Nishimura
  
  Influenza viruses and coronaviruses cause several human diseases, such as bronchitis, bronchiolitis, and pneumonia, and exacerbate bronchial asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. Human airway epithelial cells infected with these viruses release progeny viruses and inflammatory cytokines, such as Interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor-α, partly through the activation of nuclear factor kappa B. Modulation of airway damage and inflammation may modulate viral infection-induced airway and lung diseases. Human tracheal and nasal epithelial cells express proteases, including Transmembrane Protease Serine S1 Member 2 (TMPRSS2), and the proteases activate influenza viruses and coronaviruses and the subsequent replication processes of these viruses. The protease inhibitors camostat and nafamostat reduced influenza v.. Read More»
  DOI: 10.37421/2736-657X.2022.S1.005

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