Transplantation Technologies & Research

Department of Paediatrics, Istanbul University-Cerrahpaşa, 34098 Istanbul, Turkey

Publications

• Mini Review   
  Reviving Immunity: Hematopoietic Stem Cell Transplantation in Chronic Granulomatous Disease
  Author(s): Neelam Gomez*
  
  Chronic Granulomatous Disease (CGD) is a rare, inherited immunodeficiency disorder characterized by dysfunctional phagocytes, rendering affected individuals highly susceptible to recurrent and severe infections. Hematopoietic Stem Cell Transplantation (HSCT) has emerged as a promising curative therapy for CGD, offering the potential for restored immune function. This review explores the clinical application of HSCT in CGD, analyzing the historical and contemporary aspects of the procedure, associated challenges and patient outcomes. Keywords include risk assessment, donor selection, Graft-Versus-Host Disease (GVHD), conditioning regimens and long-term follow-up. The findings underscore the significance of HSCT as a potentially curative approach for CGD, while emphasizing the importance of continued research and multidisciplinary collaboration for optimal patient care... Read More»
  DOI: 10.37421/2161-0991.2024.14.271

  Abstract HTML PDF