Journal of Food & Industrial Microbiology

Department of Molecular Pathology, Children Medical Center,Teharn University of Medical Science ,Teh, Iran

Publications

• Review Article   
  Is Fragile X Syndrome Protective For Subsequent Cancers? A review of literature
  Author(s): Mohammad vaseil, Maryam Sotoudeh Anvari*, Seyed javad Mowla, Saeede Salehi, Negin Hosseini Rouzbahani and Moeinadin Safavi
  
  Fragile X Syndrome (FXS) is a key inherited basis of intellectual disability (ID) . It initiated by an expansion of over 200 CGG (cytosine-guanine-guanine) repeats in the 5 untranslated region (UTR) of the fragile X mental retardation 1 (FMR1) gene and consequently, the lack of fragile X mental retardation protein (FMRP) in the neurons causes developmental abnormalities in the brain. Although one of the largest studies on cancer risk in patient with ID demonstrated increased risk of leukemia and gastrointestinal cancers, few existing articles in FXS tell us about decrease of cancer in these patients. everyday many mechanism are described involving in FMR1 mRNA and FMRP interaction with other genes, and new information about cancer oncogenesis of FXS. This review summarizes the available articles and provides an overview of some databases contain data pertinent to cance.. Read More»
  

  Abstract PDF