Medicinal Chemistry

Department of Biochemistry, Osun State University, Osogbo, Nigeria

Publications

• Research Article   
  Ameliorative Effects of Ethanolic Leaf Extract of Physalis angulata (Ewe Koropo) on Diabetic-Induced Wistar Rats in South West Nigeria
  Author(s): Abiodun Adewolu*, A.S. Adenekan, O.F. Uzamat and O.O Ajayi
  
  Excessive consumption of foods high in calories, lack of exercise and oxidative stress play crucial roles in diabetic physiopathology, and if not diagnosed and treated early, damages to kidney, eyes, heart and nerves are inevitable. Medicinal plants have long been utilized in traditional medicine for the treatment of diseases. In this study, qualitative and quantitative phytochemicals analyses of ethanolic extract of Physalis angulata were carried out using standard biochemical methods. In addition, evaluation of the antioxidant activity and inhibitory potential of the plant extract against key enzymes associated with hyperglycemia-a symptom that characterizes diabetes were done. Antioxidant activities were determined using DPPH (2, 2-diphenyl-1-picryl-hydrazyl-hydrate), FRAP (Ferric Reducing Antioxidant Power), ABTS (2, 2l-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid), l.. Read More»
  DOI: 10.37421/2161-0444.2021.11.594

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