Bioinformatics and Molecular Biology Unit, Department of Biochemistry, Federal University of Technology Akure, Ondo State, Nigeria
Research
In silico Molecular Studies of Selected Compounds as Novel
Inhibitors for Phosphodiesterase-5 (PDE5) in the
Management of Erectile Dysfunction
Author(s): Opeyemi Iwaloye*, Olusola Olalekan Elekofehinti, Kikiowo Babatomiwa and Toyin Mary Fadipe
Erectile dysfunction is one of the major problems among men in today’s world, and is characterized by trouble getting or keeping steady erection during sexual
intercourse. Many drugs such as Viagra (a phosphodiesterase-5 inhibitor (PDE5)) are readily available in the market, but they are usually accompanied with numerous
side effects such as headache, dizziness and vision problem. More so these drugs only offer short term remedy. Hence the need of finding a new remedy to arrest
theseissues. In this study we utilized Schrodinger suite as the computational tool to screen about 2,000 compounds using PDE5 as target protein. Out of the 2,000
compounds screened, 6 leads compounds were found to be more potent compared toviagra based on binding affinity, with compound 6 and compound 4 exhibiting
highest inhibitory attributes attaining docking score of -14.819 kcal/mo.. Read More»
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