Journal of Bioanalysis & Biomedicine

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences Federal University of Oye-Ekiti, Ekiti State, Nigeria

Publications

• Research Article   
  Physicochemical and Anti-Diabetic Effect of the Crude Leaf Extract of Mallotus oppostifollous (Euphorbiaceae) in Alloxan Induced Diabetic Mice
  Author(s): Ifeanyi Peter Onyeka*, Omoirri Moses Aziakpono, Ugonna Chinwe Morikwe, Onyebuchi Hillary Nwafor and Nnamdi Markben Adione
  
  Background: Diabetes mellitus results when there is an imbalance in the production, metabolism and regulation of insulin and blood glucose respectively, in the human body. This study investigated the fresh leaf microscopy and chemomicroscopy, phytochemical, acute toxicity and the anti-diabetic potentials of Mallotus oppostifollous using the mice diabetic model. Methods: Mallotus oppostifollous was extracted using the cold maceration method with absolute methanol. The acute toxicity (LD 50) of the fraction extract was determined in mice using Lorke’s method. The antidiabetic studies were conducted using the standard protocol of alloxan induced diabetic mice. Results: The findings showed that no toxicity was observed up to 5000 mg/kg doses of the crude extract. The phytochemical screening revealed the presence .. Read More»
  DOI: 10.37421/1948-593X.2021.13.279

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