Molecular and Genetic Medicine

Familial Cancer Clinic, University Hospital Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium

Publications

• Research Article   
  The Clinical Characteristics of Breast Cancers with A Familial Risk in Which No BRCA1/2 Mutations were found are Sometimes Suggestive for A Genetic Etiology
  Author(s): Joris S*, Shahi RB, De Brakeleer S, Fontaine C, Bonduelle M, Pauwels I, Teugels E and De Grève J
  
  Aim: We investigated the patient and tumor characteristics of breast cancer patients with a high familial risk. The families in which the standard genetic testing revealed a BRCA1 or BRCA2 mutation were excluded to identify clinical characteristics that can be linked with an unknown genetic mutation. These characteristics were compared with those from patients in the same cohort in whom a mutation was found in BRCA1 or BRCA2 and to those from sporadic breast cancer cases (Belgian cancer registry). Methods: The files of familial cancer cases that underwent BRCA1/2 testing between 1994 and 2012 were retrospectively analyzed. Results: The BRCA1 related breast cancers occur at a median age of 42, BRCA2 at a median age of 44, familial non-BRCA1/2 at.. Read More»
  

  Abstract PDF