Journal of Computer Science & Systems Biology

School of Informatics, University of Edinburgh, UK

Publications

• Research Article   
  A Study on the Analysis of Personal Gut Microbiomes
  Author(s): Olga Vasieva, Anatoly Sorokin, Marsel Murzabaev, Peter Babiak and Igor Goryanin*
  
  In this case study, we validate a personalized approach to gut microbiome (GM) analysis and interpretation based on published association studies. We apply our ASAR data annotation and clustering package to a series of 10 sequenced GM’s from individuals of different ethnical and geographical backgrounds, age and health groups. The differentially presented and detectable taxonomic and functional signatures in each GM metagenome are used to predict the hosts’ characteristics via correlations established in published studies, and the predictions are being validated by available individual-associated metadata. We also test sensitivity of the routine annotation and data clustering pipeline to an individual and family-linked signatures in GM structure and functionalities, when applied to a limited number of varying samples. The number of samples was s.. Read More»
  

  Abstract PDF