Archives of Surgical Oncology

Department of Surgical Oncology, University of Gumi, Gumi, Republic of Korea

Publications

• Mini Review   
  Monoclonal Antibodies for Targeted Fluorescence-guided Surgery: A Review of Applicability across Multiple Solid Tumors
  Author(s): Petru Zurzu*
  
  Fluorescence-Guided Surgery (FGS) has emerged as a promising technique for enhancing intraoperative visualization and precision in tumor resection. Monoclonal Antibodies (mAbs) offer a targeted approach to FGS, facilitating the selective binding of fluorescent probes to tumor-specific antigens. In this review, we explore the applicability of mAbs in FGS across various solid tumors. We systematically analyze recent literature to evaluate the efficacy and safety of mAb-based FGS strategies in different tumor types, including breast cancer, colorectal cancer, glioblastoma, and others. Key aspects such as target selection, fluorescent probe conjugation, imaging modalities, and clinical outcomes are discussed. Furthermore, we address challenges and limitations associated with the clinical translation of mAb-based FGS, including antigen heterogeneity, probe pharmacok.. Read More»
  DOI: 10.37421/2471-2671.2024.10.88

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