Journal of Clinical & Medical Genomics

Department of Biomedical Data Science, Southern Medical University, Guangzhou, China

Publications

• Mini Review   
  The Magic of Deciphering the Structure and Function of the Genome
  Author(s): Pia Cosma*
  
  The human genome contains all the genetic information necessary for the development and function of a human being. However, the human genome is not a simple linear sequence of genes, but rather a complex three-dimensional structure that regulates gene expression and function. Understanding the genome architecture and function is a fundamental goal of modern genomics, and has important implications for disease diagnosis, prevention, and treatment. The genome is organized into a hierarchy of structures, with DNA packaged into chromatin, which in turn is organized into chromosomes. The basic unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins. Nucleosomes can be further compacted into higher-order chromatin structures, which regulate gene expression and other genomic functions. The three-dimensional organization of .. Read More»
  DOI: 10.37421/2472-128X.2023.11.233

  Abstract HTML PDF